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Immunological Factors

Immunological factors affecting Female Fertility

Infertility can be a complex issue influenced by genetics, lifestyle, and health status. One of the lesser-known causes of infertility is immunological factors. These factors can greatly affect female fertility, and it is essential to understand how they work to overcome them.

The Significance of Healthy & Normal Immunological Factors in Fertility

The immune system plays a vital role in maintaining the body’s health, fighting infections, and optimizing fertility. A healthy immune system ensures the body doesn’t reject the sperm or the growing fetus.

However, sometimes it can mistakenly attack healthy cells in the body, including reproductive cells. When the immune system perceives the sperm and the fetus as foreign agents, it produces antibodies to attack them.

In some cases, the immune system may create antibodies that attack sperm or the uterus lining, making it difficult for fertilization and implantation. This can lead to various fertility problems, such as miscarriages, failed IVF cycles, and sterility. Additionally, immunological factors can impact ovulatory functioning, a crucial aspect of female fertility.

A healthy and normal immunological system helps optimize fertility by protecting and maintaining the natural processes that enable successful fertilization and implantation. It also helps prevent complications like inflammation and diseases affecting fertility.

Signs to Watch

If you are experiencing one or more of the following symptoms, it’s important to consult an infertility specialist to rule out any immunological factors impacting fertility:

  • Unexplained infertility
  • Recurrent miscarriage
  • Failed IVF cycles
  • Irregular menstrual cycles
  • Elevated thyroid function

However, it is important to note that not all women with these symptoms have immunological factors at play. Only a thorough medical evaluation can help diagnose the root cause of infertility.


Diagnosing immunological factors affecting fertility can be challenging as it requires a comprehensive analysis of multiple factors. A specialized doctor will conduct various tests to determine if any antibodies in the blood may be attacking the sperm, eggs, or uterus. Some of the tests conducted may include:

  • Antinuclear antibody test
  • Antisperm antibody test
  • Antiphospholipid antibody test
  • Hysterosalpingography (HSG)


The treatment of immunological factors depends on the root cause of infertility and the severity of the antibodies in the blood. There is no one-size-fits-all approach to treating immunological factors impacting infertility, so it’s important to consult an expert infertility specialist.

Some of the treatment options that may be suggested include:

Approach to Treatment

At the clinic of Dr. Supriya Puranik, we approach the treatment of immunological factors affecting female fertility with a personalized and comprehensive approach. The treatment approach is tailored to the patient’s medical history, diagnosis, and specific immunological factors impacting fertility.

We take the time to understand our patients’ unique situations and work closely with them to develop individualized treatment plans that meet their specific needs. If immunological factors negatively impact fertility, we will work to identify the specific antibodies involved and prescribe the appropriate course of treatment.

We strive to optimize the chances of success while minimizing the risk of side effects. With a thorough understanding of the immune system’s role in fertility, we can offer expert care that helps women achieve their dream of becoming a parent.

Get in Touch:

If you’re experiencing any of these symptoms or are having trouble getting pregnant, it’s important to seek the help of a fertility specialist. Dr. Supriya Puranik is a leading expert in the field of infertility and IVF, with years of experience and a compassionate approach to patient care.

To schedule a consultation with Dr. Puranik, please don’t hesitate to get in touch with us today. You can book an appointment by calling us at +91-750251999 or filling out the contact form on our website.

We understand that infertility can be a difficult journey, and we are committed to helping you navigate this challenging time with care, expertise, and compassion. We look forward to hearing from you and helping you achieve your dream of starting a family.

About Doctor


Dr. Supriya Puranik

Gynaecologist & IVF Specialist

Often known as the last glimmer of hope for people who have lost all hope for conceiving a child, Dr. Supriya Puranik is a leading gynaecologist, high-risk obstetrician and Head of IVF & Gynaecology department at Ankura Hospital, Pune

Patient Reviews

Patient Reviews & Feedback

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  • Om Kadel

She is excellent. And as a goddess for my family. After long time I m blessed with twins baby due to her efforts only. She used to boost me with lots of positive thoughts whenever I lost the hope. You are too supportive mam. Thanks a lot.

Even the hospital staff, Nurses, mousis,house keeping staffs are at your step when ever needed when I was admitted.

The food provided is well planned according to the diet of patients by mam. Thank you very much mam for this turn over in my life after 12 years of marriage.

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  • Ashwini Sonawane

Dr. Supriya Puranik’s mam is very sweet person I have ever met. She is very caring, her ever smiling face always gives you positive wives. Staff is also very helpful and care taking during delivery, the best hospitality service I would say…
Thank you so much Dr Puranik Mam and Team. keep up the good work


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