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Repeated Implantation Failure


RIF is a medical condition that affects individuals or couples who cannot achieve a successful pregnancy despite multiple attempts at In Vitro Fertilization (IVF) or embryo transfer. RIF can have various underlying causes, making it challenging to diagnose and treat. 

We specialize in diagnosing and treating RIF by providing personalized care that considers each patient’s circumstances. This comprehensive guide will cover everything you need to know about RIF, including the causes, symptoms, diagnosis, treatment options, and advanced technological interventions available at our clinic.

Causes of Repeated Implantation Failure

Numerous factors can contribute to RIF. The causes of RIF include:

  • Age-related decline in the ovarian reserve
  • Chromosomal abnormalities in the embryo
  • Anatomical issues in the uterus, like fibroids or polyps
  • Hysteroscopic anomalies
  • Genetic disorders
  • Blood clotting disorders can lead to poor blood supply to the uterus
  • Immunological issues like increased levels of Natural Killer cells

Symptoms and Impact on Mental Health

The symptoms of RIF involve the inability to achieve a successful pregnancy after multiple IVF attempts, recurrent miscarriages, or abnormal uterine bleeding. RIF can take an emotional toll on individuals and couples struggling to conceive. The emotional impact of RIF can include feelings of grief, hopelessness, anxiety, stress, and depression.

Diagnosis and Required Exams

To diagnose RIF, Dr. Supriya Puranik uses various measures, including blood tests, ultrasounds, and endometrial biopsies. These tests help identify any underlying medical or immunological issues that might prevent successful implantation. Additionally, it is crucial to rule out anatomical problems like fibroids or polyps that can prevent implantation.

Treatment of Repeated Implantation Failure

The treatment of RIF is personalized to an individual’s specific needs and circumstances. Dr. Supriya Puranik recommends some of the most common interventions like hormonal therapy, immune therapy, and diagnostic hysteroscopy.

Hormonal Therapy

Hormonal therapy involves taking medications that regulate hormone levels in the body. Hormonal therapy for RIF aims to increase estrogen and progesterone levels to prepare the uterus for implantation.

Immune Therapy

Immune therapy aims to address issues with the body’s immune system. One common immune therapy intervention is intravenous immunoglobulin (IVIg) therapy, which involves receiving an infusion of immunoglobulin G (IgG) antibodies. The IgG antibodies help to suppress the body’s immune response, reducing the likelihood of the body rejecting the embryo.

Diagnostic Hysteroscopy

Diagnostic hysteroscopy is a minimally invasive surgical procedure that allows Dr. Supriya Puranik to examine the inside of the uterus for anatomical problems like fibroids or polyps. Hysteroscopy can also help identify and treat adhesions, which can prevent implantation.

Surgical Interventions

In some cases, surgical interventions may be necessary to correct anatomical problems impacting implantation. Surgical treatments include removing uterine septae, correcting uterine anomalies or performing a Myomectomy to remove fibroids.


Intra Cytoplasmic Sperm Injection (ICSI) is an assisted reproductive technology that injects sperm into an egg to fertilize it. This procedure can be combined with In Vitro Fertilization (IVF) to increase the chances of successful implantation.

New Technological Advancements

In addition to the abovementioned interventions, technological advancements and breakthroughs offer new avenues to treat Repeated Implantation Failure. These include embryonic genetic testing, stem cell therapy, and preimplantation genetic diagnosis (PGD).

However, these treatments may come with risks, and Dr. Supriya Puranik encourages patients to make an informed decision before undergoing any new treatments.

Get in Touch:

At Dr. Supriya Puranik‘s clinic, we understand that RIF can be a distressing experience. Our compassionate and skilled team is here to provide treatments and interventions tailored to your needs. We offer to counsel patients to help them cope with stress and anxiety. Contact us today to book a consultation with one of our fertility specialists and learn more about your options for Repeated Implantation Failure treatment.

About Doctor


Dr. Supriya Puranik

Gynaecologist & IVF Specialist

Often known as the last glimmer of hope for people who have lost all hope for conceiving a child, Dr. Supriya Puranik is a leading gynaecologist, high-risk obstetrician and Head of IVF & Gynaecology department at Ankura Hospital, Pune

Patient Reviews

Patient Reviews & Feedback

3563+ Happy Patients

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  • Om Kadel

She is excellent. And as a goddess for my family. After long time I m blessed with twins baby due to her efforts only. She used to boost me with lots of positive thoughts whenever I lost the hope. You are too supportive mam. Thanks a lot.

Even the hospital staff, Nurses, mousis,house keeping staffs are at your step when ever needed when I was admitted.

The food provided is well planned according to the diet of patients by mam. Thank you very much mam for this turn over in my life after 12 years of marriage.

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  • Ashwini Sonawane

Dr. Supriya Puranik’s mam is very sweet person I have ever met. She is very caring, her ever smiling face always gives you positive wives. Staff is also very helpful and care taking during delivery, the best hospitality service I would say…
Thank you so much Dr Puranik Mam and Team. keep up the good work


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