Starting an IVF (in vitro fertilisation) journey is an emotional, physical, and mental commitment, and one of the most commonly asked questions is: “How many injections will I need?” If you’ve landed here, chances are you’re looking for clarity on what to expect.

Whether you’re just exploring IVF or are already gearing up for the process, this blog will take you through the answers in a way that’s easy to understand—without the heavy medical lingo. 

Before we dig into the details, let’s acknowledge how intimidating the idea of daily injections can be. If you’re nervous about needles, you’re not alone.

Many people feel the same way at the start. However, understanding the purpose of these injections and how they fit into the IVF process can help alleviate some of that fear. 

The injections during IVF aren’t random—they’re carefully planned steps that form the backbone of the ivf treatment. Their job? To regulate and stimulate your body in preparation for retrieving eggs, fertilising them, and ultimately, transferring embryos. 

IVF injections aren’t “one-size-fits-all.” The exact number and types of injections depend on your specific protocol and individual factors like age, hormone levels, and ovarian reserve. However, here’s a breakdown of the types you’re most likely to encounter:

1. Ovarian Stimulation Medications 

Purpose: To stimulate your ovaries to produce multiple eggs rather than the usual single egg per cycle. 

Common Medications:

• Gonadotropins (e.g., Gonal-F, Menopur, or Follistim): These help your ovaries mature multiple eggs simultaneously. 

  Frequency: Administered once or twice daily for about 8-14 days, depending on how your ovaries respond.

2. Preventing Premature Ovulation 

  
Purpose: To stop your body from releasing eggs too early. 

Common Medications:

• GnRH Antagonists (e.g., Cetrotide or Ganirelix): These ensure your eggs don’t ovulate before they’re retrieved. 
• GnRH Agonists (e.g., Lupron): Sometimes used for the same purpose but may be part of a different IVF protocol. 

  Frequency: Typically starts mid-stimulation and continues daily until the trigger injection.

3. The Trigger Shot 

  
Purpose: To finalise egg development and prepare them for retrieval. 

Common Medications:

• hCG (e.g., Ovitrelle) or a combination like Lupron and hCG. 

 Frequency: Given only once, typically 36 hours before the egg retrieval procedure.

4. Progesterone Support After Egg Retrieval 

  Purpose: To prepare and support the lining of your uterus for implantation. 

  Common Medications:

• Progesterone-in-Oil (PIO) injections 

  Frequency: Daily, starting after egg retrieval until 10-12 weeks of pregnancy if successful.

Many clinics are now offering progesterone alternatives like vaginal suppositories or tablets, so you might not need ongoing injections for this phase.

The total number of injections typically falls within the 20-60 range across a single IVF cycle. 

Here’s a quick breakdown by stage (assuming an average IVF protocol): 

• Ovarian Stimulation Medications: 10-28 injections 
• GnRH Antagonist or Lupron Dosages: 5-14 injections 
• Trigger Shot: 1 injection 
• Progesterone Support (if injections are used): up to 30 injections 

Keep in mind these numbers can vary significantly. Some protocols, such as a “mini-IVF” or a natural cycle IVF, might involve fewer medications and injections.

1. Get Comfortable with the Process 

Ask your doctor or nurse to demonstrate the injections for you at your first appointment. Many clinics offer thorough instructions, and some even provide tutorial videos. 

Pro Tip: Mark your calendar with not just the dates of injections but the specific timing for each dose. Timing is critical in IVF treatments. 

2. Use Numbing Techniques 

If you’re anxious about the needle, try numbing the area with an ice pack or numbing cream prior to the injection. It reduces the sting considerably. 

3. Rotate Injection Sites 

Constantly using the same spot can cause soreness and bruising. Rotate between the left and right sides of your abdomen or upper thighs to alleviate discomfort. 

4. Establish a Routine 

Make injecting a predictable part of your day—for example, always in the evening or early morning. This reduces the mental burden of trying to remember when to inject. 

5. Don’t Hesitate to Ask for Support 

If administering shots yourself feels overwhelming, ask your partner, a friend, or a family member to help. It can feel less daunting with support. 

It’s okay—needle fear is more common than you think! Here are a few extra strategies to help you manage it:

• Distract Yourself with music, TV, or deep breathing techniques during injections. 
• Focus on the Goal. Remind yourself that every injection is bringing you closer to your future family. 
• Celebrate Small Wins. Each time you get through an injection, treat yourself to something small—a piece of chocolate, a walk, or even a celebratory sticker on your calendar. 

One thing that surprises many people is how empowering the process can feel after getting comfortable with it.

While the idea of dozens of injections may feel overwhelming at first, each step becomes routine over time.

Parents who’ve gone through IVF often say they felt a sense of pride in how they engaged in this hands-on process to create their family. 

While the number of injections during IVF might sound daunting, breaking it down into stages makes it less overwhelming. Each needle has a purpose, and with every dose, you’re one step closer to achieving your dream. 

Are you ready to take the next step? Speak with your fertility specialist in pune about your unique IVF protocol today, or contact a clinic to get started. Every journey begins with that first step, and yours could be just around the corner. 

CTA: 

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• About Author

  Dr. Supriya Puranik

  Gynaecologist & IVF Specialist
  
  MMC -072514 (1993)

Dr. Supriya Puranik, a renowned gynaecologist and infertility expert, leads the IVF & Gynaecology department at Sahyadri Hospitals Momstory in Shivaji Nagar, Pune. She is committed to helping couples overcome infertility challenges.